Publications by authors named "D G Hanisch"
The thermodynamic state of the interface in which an enzyme is embedded can regulate the enzymatic activity. Indeed, it has been demonstrated by others and us that close to the maximum in compressibility, the activity of the enzyme is at a maximum as well. Pulses propagating along the interface can modulate the interface state and were demonstrated to be able to modulate the activity of interface-associated acetylcholinesterase (AChE).
View Article and Find Full Text PDFBackground: With the advent of more intensive rhythm monitoring strategies, ventricular arrhythmias (VAs) are increasingly detected in Fontan patients. However, the prognostic implications of VA are poorly understood. We assessed the incidence of VA in Fontan patients and the implications on transplant-free survival.
View Article and Find Full Text PDFBackground: An implantable cardioverter-defibrillator (ICD) in the pediatric patient (and the precipitating events that led to ICD placement) can be traumatic for patients and their families and may lead to posttraumatic stress disorder (PTSD).
Objectives: This study aimed to estimate the prevalence of PTSD in pediatric patients with an ICD and their parents and identify the factors associated with PTSD incidence.
Methods: Pediatric participants with an ICD aged 8-21 years and parents of children aged 0-21 years completed surveys that included demographic characteristics and PTSD measures.
Article Synopsis
- Overexpression of class I histone deacetylases (HDACs) in glioblastoma cells leads to increased resistance to the chemotherapy drug temozolomide (TMZ) by activating the DNA damage response (DDR).
- The study found that class I HDACs stimulate the expression of RAD18, an E3 ubiquitin ligase, which helps glioma cells survive DNA damage from TMZ by promoting lesion bypass.
- Inhibiting HDACs reduces RAD18 expression, making glioma cells more susceptible to TMZ, suggesting that targeting HDACs could be a potential therapeutic strategy to enhance treatment effectiveness against resistant glioblastoma.
Background: To reduce HIV incidence among adolescent girls who sell sex (AGSS) in Zimbabwe, we need to better understand how vulnerabilities intersect with HIV infection and how those living with HIV engage in care.
Methods: In 2017, we conducted social mapping in 4 locations in Zimbabwe and recruited girls aged 16-19 years who sell sex, using respondent-driven sampling or census sampling methods. Participants completed a questionnaire and provided finger prick blood samples for HIV antibody testing.