Prevalence estimates and nature of online child sexual exploitation and abuse: a systematic review and meta-analysis.

Background: Online child sexual exploitation and abuse (OCSEA) is a global health issue. The aim of this global systematic review and meta-analysis was to better understand the prevalence and nature of OCSEA on a global scale.

Methods: Comprehensive literature searches were done in six UN languages (Arabic, Chinese, English, French, Russian, and Spanish) and multiple databases, for records published between Jan 1, 2010, and Sept 30, 2023.

Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development.

p53 is a potent transcription factor that is crucial in regulating cellular responses to stress. Mutations in the gene are found in >50% of human cancers, predominantly occurring in the DNA-binding domain (amino acids 94-292). The Y220C mutation accounts for 1.

The economic burden of child marriage in Nigeria.

Background: Child marriage affects young boys and girls, especially in low and middle income countries, where it represents a dereliction of child rights, duty of care, and the promotion of public health. In Nigeria, child marriage presents a significant challenge, especially for girls, impacting education, health, and national development profoundly. Despite the importance of comprehending the effects of child marriage on health and education and quantifying its economic impact on Nigerian society through these crucial domains, there remains limited knowledge on this matter.

Implementation and Impact of a Lifting Cushion for Care Home Residents Who Have Fallen.

Introduction: Falls are a global public health problem and the second leading cause of death from unintentional injury. Globally, approximately 30%-50% of people living in nursing or residential care homes fall each year. Falls have an impact on quality of life and morbidity.

A content analysis of metrics on online child sexual exploitation and abuse used by online content-sharing services.

Background: A critical step in improving the response to and monitoring of online child sexual exploitation and abuse (OCSEA) is the need to standardize the data that are collected, stored, and analyzed that effectively measure change in the frequency, nature and risk of OCSEA over time.

Objective: The objective of the content analysis was to investigate the metrics used by online content-sharing platforms in their efforts to combat OCSEA.

Methods: A content analysis was undertaken on 19 online content-sharing services' transparency reports on their metrics related to OCSEA.