Opposite Effects of CRABP1 and CRABP2 Homologs on Proliferation of Breast Cancer Cells and Their Sensitivity to Retinoic Acid.

Resistance of tumor cells to retinoic acid (RA), a promising therapeutic agent, is the major factor limiting the use of RA in clinical practice. The mechanisms of resistance to RA are still poorly understood. Cellular Retinoic Acid Binding Proteins, CRABP1 and CRABP2, are essential mediators of RA signaling, but role of the two CRABP homologs in regulating cellular sensitivity to RA has not been well studied.

How to Draw on Narrative to Mitigate Ageism.

Ageism is so structurally integrated and normalized in US health care that it is generally unnoticed by clinicians, despite its effects on the medical care and lives of older adults. Clinicians often lack time, incentives, and opportunities to pause and fully consider the perspective of older adults, especially those with mental illness. As a result, clinicians might infantilize older adults and pathologize or dismiss their preferences, values, and capacity for growth.

Isolation and Characterization of Extracellular Vesicles from Gastric Juice.

EVs are involved in local and distant intercellular communication and play a vital role in cancer development. Since EVs have been found in almost all body fluids, there are currently active attempts for their application in liquid diagnostics. Blood is the most commonly used source of EVs for the screening of cancer markers, although the percentage of tumor-derived EVs in the blood is extremely low.