Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic.

SARS-CoV-2 variants are mainly defined by mutations in their spike. It is therefore critical to understand how the evolutionary trajectories of spike affect virus phenotypes. So far, it has been challenging to comprehensively compare the many spikes that emerged during the pandemic in a single experimental platform.

Modeling nearshore total phosphorus in Lake Michigan using linked hydrodynamic and water quality models.

Although the offshore water of Lake Michigan has been below the Great Lakes Water Quality Agreement (GLWQA) total phosphorus (TP) spring target concentration of 7 μg L for several decades, higher TP concentrations occur in the nearshore, contributing to the resurgence of and other nutrient related issues. The most recent update of the GLWQA specifically calls for the assessment of current nearshore conditions. Such assessment would require an intensive monitoring program supported by water quality models.

Electrochemically-Formed Disordered Rock Salt ω-Li VMoO as a Fast-Charging Li-Ion Electrode Material.

Electrochemically-formed disordered rock salt compounds are an emerging class of Li-ion electrode materials for fast-charging energy storage. However, the specific factors that govern the formation process and the resulting charge storage performance are not well understood. Here, we characterize the transformation mechanism and charge storage properties of an electrochemically-formed disordered rock salt from VMoO (VMO).

Correction of L5 Tilt in 2-Row Vertebral Body Tethering Versus Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis.

Study Design: Single-center retrospective cohort study.

Objective: To compare the correction of fractional curve and L5 tilt in 2RVBT versus PSF with LIV in the lumbar spine.

Summary Of Background Data: Vertebral body tethering, an AIS fusion-alternative, avoids rigid constructs, allowing for lower instrumented vertebra (LIV) selection.

Molecular mechanism targeting condensin for chromosome condensation.

Genomes are organised into DNA loops by the Structural Maintenance of Chromosomes (SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene expression and chromosome segregation, but how SMC activity is specifically targeted is unclear. Here, we define the molecular mechanism targeting the condensin SMC complex to specific chromosomal regions in budding yeast.