[Variants and early symptoms of congenital diseases of larynx and trachea].

Congenital laryngeal and tracheal anomalies found in 1980-1995 in 91 children consisted of vascular tumors, laryngeal membranes, laryngeal cartilage anomaly, tracheomalacia, laryngeal papillomatosis, cysts, stridor (36.2%, 16.5%, 13.

[Molecular-biological aspects of juvenile respiratory papillomatosis and its combined treatment].

Systemic clinical and molecular-biological analyses of cause-effect relations between human papillomatosis virus (HPV) and juvenile respiratory papillomatosis (JRP) disclosed general mechanism of HPV infection initiation and stages of tumor genesis. However, there is no consent on the universal etiopathogenetic approach to the disease treatment. The authors give some results to the disease treatment.

[Assessment of the formation of antibodies to interferon in patients with juvenile respiratory papillomatosis on interferon therapy].

Children with juvenile respiratory papillomatosis given alpha 2-INF had antibodies to alpha 2-INF in 67.7% of cases. In children treated with intramuscular recombinant alpha 2-INF (reaferon) alone antibodies to INF occurred in 92.

[Antibodies to alpha-2A interferon in children with juvenile respiratory papillomatosis].

Follow-up of 36 JRP children and 12 controls (as shown by solid-phase enzyme immunoassay) has revealed that antibodies to IFN-alpha 2a with titers 1:20 to 1:1280 were present in 73.7% (14 of 19) of patients after interferon therapy and in 5.8% (1 of 17) of those who have not received interferon.

[Laser surgery in laryngeal diseases in children (preliminary report)].

YAG-Nd-laser Raduga-1 was employed in 25 operations performed in 22 children for scarring stenosis, papillomatosis and vascular tumors of the larynx, oropharynx and trachea. Contact irradiation resulted in 1 serious complication only which was successfully corrected. The technique may be used for removal of vascular tumors, recanalisation of the larynx in massive scars.