Publications by authors named "D G Carrick"
Article Synopsis
- The study investigates the link between atherosclerosis (plaque buildup in arteries) and types of myocardial ischemia (insufficient blood flow to the heart) in patients without significant coronary artery blockage (INOCA).
- It employs advanced invasive tests to assess coronary microvascular function and quantifies plaque burden using the Gensini score, which takes into account the severity of artery blockage.
- Findings reveal that higher Gensini scores correlate with poorer microvascular function, and different INOCA endotypes (like microvascular angina and vasospastic angina) show variations in plaque scores, indicating the complexity of heart conditions in patients without obvious artery blockage.
Association of radiation-induced epilation and interventional neuroradiology procedures.
J Med Imaging Radiat Oncol
October 2024
Introduction: The aim of this study is to quantify the association of temporary epilation following interventional neuroradiology (INR) procedures and compare the peak skin dose (D) threshold to published values.
Methods: Gold Coast University Hospital (GCUH) is a major centre for INR with over 500 primarily interventional procedures performed every year. D is calculated when the reference air kerma (K) exceeds 3 Gy.
Research conducted over the past 15+ years has identified hundreds of common germline genetic variants associated with cancer risk, but understanding the biological impact of these primarily non-protein coding variants has been challenging. The National Cancer Institute sought to better understand and address those challenges by requesting input from the scientific community via a survey and a 2-day virtual meeting, which focused on discussions among participants. Here, we discuss challenges identified through the survey as important to advancing functional analysis of common cancer risk variants: 1) When is a variant truly characterized; 2) Developing and standardizing databases and computational tools; 3) Optimization and implementation of high-throughput assays; 4) Use of model organisms for understanding variant function; 5) Diversity in data and assays; and 6) Creating and improving large multidisciplinary collaborations.
View Article and Find Full Text PDFBackground: The prognostic significance of various microvascular injury (MVI) patterns after ST-segment elevation myocardial infarction (STEMI) is not well known.
Objectives: This study sought to investigate the prognostic implications of different MVI patterns in STEMI patients.
Methods: The authors analyzed 1,109 STEMI patients included in 3 prospective studies.
Article Synopsis
- The microvascular resistance reserve (MRR) is a new index developed to evaluate the vasodilatory capacity of the microcirculation, particularly relevant for patients with ST-segment elevation myocardial infarction (STEMI), whose prognostic value was previously unknown.
- This study analyzed data from 1,265 STEMI patients, focusing on a subgroup where both MRR and index of microcirculatory resistance (IMR) were available, to compare their effectiveness in predicting long-term outcomes.
- The findings revealed that MRR is a significant predictor of long-term all-cause mortality or heart failure hospitalization, with a cutoff value of 1.25 indicating higher risk when below this level.