Publications by authors named "D G Broadbent"
Autophagy is an essential cellular recycling process that maintains protein and organelle homeostasis. ATG9A vesicle recruitment is a critical early step in autophagy to initiate autophagosome biogenesis. The mechanisms of ATG9A vesicle recruitment are best understood in the context of starvation-induced non-selective autophagy, whereas less is known about the signals driving ATG9A vesicle recruitment to autophagy initiation sites in the absence of nutrient stress.
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- This study focused on optimizing CBCT protocols for head and neck radiotherapy using a 3D-printed phantom to improve patient positioning and reduce radiation dose.
- Ten different CBCT protocols were tested, revealing that some protocols could cut radiation exposure by over 50% while still providing good image quality for treatment setup.
- The research highlights the need for tailored imaging protocols based on the area being treated, indicating that future work is required to further refine these protocols for adaptive radiotherapy and to establish effective dose measurements.
This study aims to identify and evaluate suitable and stable materials for developing a head and neck anthropomorphic multimodality phantom for radiotherapy purposes. These materials must mimic human head and neck tissues in both computed tomography (CT) and magnetic resonance imaging (MRI) and maintain stable imaging properties over time and after radiation exposure, including the high levels associated with linear accelerator (linac) use.Various materials were assessed by measuring their CT numbers and T1 and T2 relaxation times.
View Article and Find Full Text PDFAmino Acids for Renal Protection: Promising, but Cautiously So.
J Cardiothorac Vasc Anesth
December 2024
Article Synopsis
- Type 2 diabetes (T2D) involves insulin resistance and abnormal insulin secretion, and this study compares the effects of two treatments: liraglutide (which boosts insulin secretion) and pioglitazone (which reduces insulin resistance) on heart health.
- The study involved 41 T2D patients and used various methods, including advanced imaging, to assess heart performance and function over two treatment periods with an 8-week washout in between.
- Results showed that pioglitazone significantly improved left ventricular (LV) mass and function, while liraglutide enhanced myocardial blood flow and perfusion reserve, indicating different benefits of each treatment approach for heart health in T2D patients.