Publications by authors named "D G Bratt"
Article Synopsis
- Since late 2020, new SARS-CoV-2 variants have frequently appeared, showing differences that may help them evade immunity from past infections.
- The Early Detection group within the NIH's SARS-CoV-2 program utilizes bioinformatics to track these variants' emergence, spread, and traits, highlighting important ones for further study.
- Since April 2021, this group has successfully prioritized variants each month, assisting NIH researchers by providing timely data on SARS-CoV-2 evolution for guiding experiments.
Article Synopsis
- The emergence of new SARS-CoV-2 variants threatens the effectiveness of immunity from previous infections or vaccinations.
- To tackle this issue, the NIH launched the SARS-CoV-2 Assessment of Viral Evolution (SAVE) program for real-time assessment of variant risks that might impact transmission and vaccine efficacy.
- The program focuses on gathering and analyzing data on emerging variants and their effects on immunity, using animal models, while also addressing future challenges in monitoring rapidly evolving viruses.
A therapeutic vaccine that induces lasting control of HIV infection could eliminate the need for lifelong adherence to antiretroviral therapy. This study investigated a therapeutic DNA vaccine delivered with a single adjuvant or a novel combination of adjuvants to augment T cell immunity in the blood and gut-associated lymphoid tissue in SIV-infected rhesus macaques. Animals that received DNA vaccines expressing SIV proteins, combined with plasmids expressing adjuvants designed to increase peripheral and mucosal T cell responses, including the catalytic subunit of the E.
View Article and Find Full Text PDFA simple novel training model for teaching suprapubic catheter (SPC) exchange.
Actas Urol Esp (Engl Ed)
October 2020
Objectives: To develop a suprapubic catheter (SPC) training model as no specific realistic training model exists to replicate SPC exchange where a catheter tract is present.
Materials And Methods: We describe a novel, anatomically realistic, animal simulator model for use in SPC training, which was trialed at a national urology simulation boot camp by new urology trainees and validated by expert urologists. A scale reproduction of an abdominal wall was created using a porcine abdominal wall.
Context: Bladder pain syndrome/interstitial cystitis (BPS/IC) is a poorly understood chronic debilitating condition. Surgery is reserved for severe refractory cases; however, there is no consensus on patient selection or optimal approach.
Objective: To evaluate the evidence relating to the safety and efficacy of surgical interventions for treating BPS/IC.