Publications by authors named "D G Blazer"
Purpose: Optimal treatment of retroperitoneal sarcoma (RPS) remains undefined. Here, we report the feasibility of using high-dose boost radiation (3-4 Gy) to the central part of the tumor in patients with unresectable RPS.
Methods And Materials: Five patients with unresectable RPS were treated with radiation therapy using a central boost technique with intensity modulated radiation therapy.
As the numbers of older adults continue to increase globally, the need for facilitating healthy aging has become critical. While a physically healthy lifestyle, including exercise and diet, is important, recent research has highlighted a major impact of psychosocial determinants of health, such as resilience, wisdom, positive social connections, and mental well-being, on whole health. This article focuses on keeping the mind and brain healthy with psychosocially active aging.
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- The study focuses on pancreatic acinar cell carcinoma (pACC), a rare type of pancreatic cancer, highlighting its clinical characteristics, genetic mutations, and patient survival outcomes.
- A total of 61 patients who underwent surgery between 1999 and 2022 were analyzed, showing a median overall survival of 73 months and a recurrence-free survival of 22 months; those with oligometastatic disease had even better outcomes.
- Significant genetic findings included mutations in core genes related to DNA repair pathways in 26% of patients, indicating potential avenues for targeted treatment.
Article Synopsis
- Ampullary adenocarcinoma (AA) shows clinical and genetic diversity, and a new genomic classifier may improve patient classification beyond traditional methods, but it needs validation before being widely used.
- A study involving 192 patients with AA assessed the accuracy of this genomic classifier against standard histology to see if it could predict survival outcomes.
- Results indicated a 55% agreement between genomic and histological classifications; however, while histological subtypes did not predict survival, the genomic scores did correlate with survival probabilities, suggesting the genomic approach might be more effective.
Article Synopsis
- Desmoid tumors (DTs) are uncommon, non-metastasizing growths that can behave aggressively locally, with a shift in management from traditional surgery to active surveillance.
- A review of 103 patients showed a significant decrease in surgical resection rates over time, indicating a preference for monitoring rather than immediate intervention.
- The study highlights improved treatment-free survival for those under active surveillance, aligning with updated guidelines from expert panels advocating for this approach.