Publications by authors named "D Fukushi"
Article Synopsis
- - Cholangiocarcinoma is a deadly cancer with few treatment options, and researchers have identified the gene FADS2 as crucial for its tumor growth.
- - Depleting FADS2 led to reduced tumor growth and cell division, as well as decreased ability of cancer cells to migrate and form spheres, while increasing cell death and markers for ferroptosis.
- - Analysis showed that when FADS2 was knocked down, levels of triglycerides and cholesterol esters dropped, which lowered energy production and reduced the aggression of cancer cells.
Article Synopsis
- Esophageal cancers that penetrate the muscularis mucosa or submucosa can have a risk of lymph node metastasis after endoscopic resection, but the patterns of metastatic recurrence post-treatment are not well-studied.
- Researchers analyzed data from 220 patients in Japan who received additional treatments (esophagectomy, chemoradiotherapy, or radiation) after endoscopic resection between 2006 and 2017 to identify risk factors for metastatic recurrence.
- They found that lymphatic invasion is a key risk factor for recurrence, and while both esophagectomy and chemoradiotherapy show similar risks for metastasis, esophagectomy tends to have higher locoregional recurrence but better survival rates for patients who do experience
Background And Aim: We previously identified that ever-smoking and severe gastric atrophy in pepsinogen are risk factors for synchronous gastric cancers (SGCs). This study aimed to determine the association of alcohol drinking status or alcohol-related genetic polymorphism with SGCs and also stratify their risk.
Methods: This multi-center prospective cohort study included patients who underwent endoscopic submucosal dissection for the initial early gastric cancers at 22 institutions in Japan.
Cholangiocarcinoma (CCA) is one of the most difficult malignancies to treat as the therapeutic options are limited. Although several driver genes have been identified, most remain unknown. In this study, we identified a failed axon connection homolog (FAXC), whose function is unknown in mammals, by analyzing serially passaged CCA xenograft models.
View Article and Find Full Text PDFIntroduction: Detecting non-cavitary epithelioid cell granuloma by gastrointestinal biopsy is important in the initial diagnosis of Crohn's disease (CD). In the present study, we aimed to determine the rate of granuloma detection by gastrointestinal biopsy according to the number of biopsies performed.
Methods: The present study included patients newly diagnosed with CD at our hospital between April 2017 and March 2023.