Publications by authors named "D Fudge"

Myxine limosa is a burrowing species of hagfish that occurs in the western North Atlantic in areas with muddy substrate and at depths generally greater than 100 meters. Burrowing of M. limosa has been observed from submersibles, but little is known about the behavior of these animals within the substrate or the biomechanical mechanisms involved.

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Introduction: Clinicians caring for adults with borderline personality disorder (BPD) in acute settings such as the emergency department (ED) have little evidence/guidance to base decisions on. Specific/detailed guidance for managing BPD in the ED is needed given the morbidity and mortality risks, high service utilisation, unique challenges and risk of iatrogenic interventions. The primary objective of this study is to use a consensus method to develop a guideline for managing adults with BPD in the ED.

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Article Synopsis
  • Intracellular Zn2+ levels rise due to neuronal depolarization, but its immediate effects on neuron function are not well understood.
  • Elevated Zn2+ concentrations decrease the movement of lysosomes and mitochondria in primary rat hippocampal neurons and HeLa cells by inhibiting motor proteins without affecting their binding to microtubules.
  • Zn2+ binds directly to microtubules and promotes the detachment of specific proteins (like tau and DCX) from them, indicating that Zn2+ plays a crucial role in regulating axonal transport and related microtubule processes.
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Hagfishes defend themselves from gill-breathing predators by producing large volumes of fibrous slime when attacked. The slime's effectiveness comes from its ability to clog predators' gills, but the mechanisms by which hagfish slime clogs are uncertain, especially given its remarkably dilute concentration of solids. We quantified the clogging performance of hagfish slime over a range of concentrations, measured the contributions of its mucous and thread components, and measured the effect of turbulent mixing on clogging.

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When attacked, hagfishes produce a soft, fibrous defensive slime within a fraction of a second by ejecting mucus and threads into seawater. The rapid setup and remarkable expansion of the slime make it a highly effective and unique form of defense. How this biomaterial evolved is unknown, although circumstantial evidence points to the epidermis as the origin of the thread- and mucus-producing cells in the slime glands.

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