Publications by authors named "D Friedrich"
The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly and disassembly have started to emerge with the possibility to follow labeled sarcomere components. Here, we generated the mCherry knock-in at titin's Z-disk to study skeletal muscle development and remodeling.
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- Parkinson's disease (PD) is increasingly recognized as a public health issue, particularly in lower-income countries where data is limited.
- A systematic review of literature identified 57 relevant studies from various regions, revealing significant geographical differences in PD prevalence, with numbers ranging from 49 to 1081 per 100,000 population.
- The study found that PD prevalence increases with age and is influenced by socioeconomic factors such as GDP per capita, highlighting the need for better data collection and standardized methodologies across different populations.
Incorporating organic semiconductor building blocks as spacer cations into layered hybrid perovskites provides an opportunity to develop new materials with novel optoelectronic properties, including nanoheterojunctions that afford spatial separation of electron and hole transport. However, identifying organics with suitable structure and electronic energy levels to selectively absorb visible light has been a challenge in the field. In this work, we introduce a new lead-halide-based Ruddlesden-Popper perovskite structure based on a visible-light-absorbing naphthalene-iminoimide cation (NDI-DAE).
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- Shorter hip stems like the Fitmore stem show promise in mid-term outcomes, but there's limited long-term data on their performance in total hip arthroplasties (THAs) after 10 years.
- The study involved 100 THAs with no aseptic loosening revisions after a mean follow-up of over 11 years, noting cortical hypertrophy (CH) in 26% of cases, particularly in specific hip zones.
- Larger stem sizes and greater axial subsidence were linked to higher CH rates; however, patients with or without CH had similar hip function scores, highlighting the need for careful patient selection and stability during surgery.
Solution NMR is typically applied to biological systems with molecular weights < 40 kDa whereas magic-angle-spinning (MAS) solid-state NMR traditionally targets very large, oligomeric proteins and complexes exceeding 500 kDa in mass, including fibrils and crystalline protein preparations. Here, we propose that the gap between these size regimes can be filled by the approach presented that enables investigation of large, soluble and fully protonated proteins in the range of 40-140 kDa. As a key step, ultracentrifugation produces a highly concentrated, gel-like state, resembling a dense phase in spontaneous liquid-liquid phase separation (LLPS).
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