Publications by authors named "D Freudenstein"
Background: Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system affecting approximately 2.8 million people worldwide. In addition to genetic and environmental factors, various lifestyle factors contribute to disease development and progression.
View Article and Find Full Text PDFBackground: Recent studies provide increasing evidence for a relevant role of lifestyle factors including diet in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis (MS). While the intake of saturated fatty acids and elevated salt worsen the disease outcome in the experimental model of MS by enhanced inflammatory but diminished regulatory immunological processes, sugars as additional prominent components in our daily diet have only scarcely been investigated so far. Apart from glucose and fructose, galactose is a common sugar in the so-called Western diet.
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- Atrophy of both white and grey matter in the brains of people with multiple sclerosis (pwMS) occurs early and has significant clinical implications, which can be measured using MRI scans and automated software tools like "md brain."
- This study looked at brain volumes from routine MRI scans of 53 pwMS, comparing those with higher disability scores (EDSS ≥ 3.5) and longer disease duration (≥ 10 years) to those with lower scores and shorter disease duration, as well as considering the impact of immunotherapy.
- Results indicated that pwMS with higher EDSS scores and longer disease duration had notably smaller total brain and regional grey matter volumes, particularly in various lobes, and that those not receiving immunotherapy
Genome-wide association studies identified a single nucleotide polymorphism (SNP) downstream of the transcription factor Sox8, associated with an increased risk of multiple sclerosis (MS). Sox8 is known to influence oligodendrocyte terminal differentiation and is involved in myelin maintenance by mature oligodendrocytes. The possible link of a Sox8 related SNP and MS risk, along with the role of Sox8 in oligodendrocyte physiology prompted us to investigate its relevance during de- and remyelination using the cuprizone model.
View Article and Find Full Text PDFLung cancer poses the greatest cancer-related death risk and males have poorer outcomes than females, for unknown reasons. Patient sex is not a biological variable considered in lung cancer standard of care. Correlating patient genetics with outcomes is predicted to open avenues for improved management.
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