Publications by authors named "D Fountain"
In clinical trials, the percentage of patients discontinuing treatment with ocrelizumab due to adverse events was low. However, real-world populations are often more diverse than randomized controlled trials (RCTs), therefore it is important to assess discontinuation rates in real-world studies. This systematic literature review (SLR) was conducted to identify real-world discontinuation and persistence data for ocrelizumab in studies of patients with relapsing remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS).
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- Neurocristopathies like CHARGE syndrome are linked to abnormal development of neural crest cells, mainly due to genetic mutations in the CHD7 gene, which is crucial for chromatin remodeling.
- Researchers used epigenomic profiling of neural crest cells in chick and human models to identify enhancers that control the expression of CHD7.
- The study established connections between transcription factors and enhancers specific to neural crest cells, highlighting the gene's role in a broader regulatory network and providing insights for better understanding CHARGE syndrome cases.
Background: Outcomes of patients with opioid use disorder undergoing elective procedures have been well studied, but research is lacking in the orthopaedic trauma population.
Aim: The aim was to compare perioperative pain and morphine equivalents required by patients with versus without opioid use disorder following intramedullary nail fixation of femoral or tibial fractures.
Methods: We conducted a retrospective review of all patients with isolated femoral or tibial diaphyseal fractures treated with intramedullary nail fixation.
Objectives: Neighborhood socioeconomic status, as measured by area deprivation index (ADI) is associated with longer length of stay (LOS) after surgery for hypoplastic left heart syndrome. We tested the hypothesis that LOS is associated with ADI in a large cohort of congenital heart disease (CHD) surgical cases of varying severity and sought to determine which other components of the ADI accounted for any associations.
Design: Retrospective analysis of a curated dataset.
Background: Sudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family counseling and cascade screening. The objective of this study was to characterize genetic variation in an SDY cohort using whole genome sequencing.
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