Publications by authors named "D Foran"
Cardiovascular disease is a leading cause of morbidity and mortality. New research elucidates increasingly complex relationships between cardiac and metabolic health, giving rise to new possible therapeutic targets. Sphingolipids are a heterogeneous class of bioactive lipids with critical roles in normal human physiology.
View Article and Find Full Text PDFBackground: Academic institutions benefit from researchers adopting leadership positions and, subsequently, leadership development programmes are of increasing importance. Despite this, no evaluation of the evidence basis for leadership development programmes for healthcare researchers has been conducted. In this study, the authors reviewed leadership development programmes for healthcare researchers and aimed to identify their impact and the factors which influenced this impact.
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- Large-scale collaboration in oncology research is essential for advancing cancer biology, precision oncology, and population sciences, which requires innovative data management and analytic tools.
- The informatics community plays a crucial role in automating the organization of diverse clinical data types, including molecular tests and diagnostic imaging, to address the complexities of cancer progression.
- The paper presents a new Clinical & Research Data Warehouse (CRDW) that supports multimodal data, such as genomics and radiology images, integrating machine-learning tools for deeper insights into tumor characteristics beyond traditional methods.
Infertility affects 15% of couples worldwide and in approximately 50% of cases the cause is secondary to an abnormality of the sperm. However, treatment options for male infertility are limited and empirical use of hormone stimulation has been utilised. We review the contemporary data regarding the application of hormone stimulation to treat male infertility.
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- Hormonal therapy's role in improving sperm retrieval success rates for men with non-obstructive azoospermia (NOA) is debated, especially since standard guidelines do not recommend its use but many patients still try it before surgical retrieval.
- A systematic review and meta-analysis aimed to compare sperm retrieval rates in men with NOA receiving hormonal therapy versus those who did not, while also examining differences based on hormone levels.
- Findings from 22 studies indicated that hormonal therapy significantly increased sperm retrieval rates, with an odds ratio of 1.96, suggesting it can be beneficial when used prior to surgical sperm extraction.