Publications by authors named "D Flis"
Article Synopsis
- - The study investigated whether swim training can improve copper metabolism in the skeletal muscles of mice with amyotrophic lateral sclerosis (ALS), analyzing the effects at different disease stages.
- - Results indicated that ALS negatively impacts copper levels and related metabolism proteins in mice, with significant changes observed by the terminal stage of the disease, including a notable decrease in copper importer protein (CTR1) and increases in copper chaperone and exporter proteins.
- - The findings suggest that while swim training has a moderate effect on copper metabolism, incorporating water exercise into rehabilitation programs could help enhance the quality of life for ALS patients.
Background And Aims: This study evaluated whether stored iron determines the adaptive response induced by Nordic walking (NW) training combined with 10 hours' time-restricted eating (TRE) in older adults.
Trial Design And Methods: Twenty-four participants underwent 12-week NW training supported by 10 h of TRE. The group was divided due to baseline ferritin concentration low < 75 ng/ml (LF) and high level ≥ 75 ng/ml (HF).
Amyotrophic lateral sclerosis (ALS) may result from the dysfunctions of various mechanisms such as protein accumulation, mitophagy, and biogenesis of mitochondria. The purpose of the study was to evaluate the molecular mechanisms in ALS development and the impact of swim training on these processes. In the present study, an animal model of ALS, SOD1-G93A mice, was used with the wild-type mice as controls.
View Article and Find Full Text PDFSwim training has increased the life span of the transgenic animal model of amyotrophic lateral sclerosis (ALS). Conversely, the progress of the disease is associated with the impairment of iron metabolism and insulin signaling. We used transgenic hmSOD1 G93A (ALS model) and non-transgenic mice in the present study.
View Article and Find Full Text PDFIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, demonstrated the highest activity in the enzymatic assay with an IC value of 8.
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