Publications by authors named "D Filipova"
Article Synopsis
- The Roma population, numbering between 10 to 14 million worldwide, faces unique genetic challenges due to a high level of consanguinity, resulting in specific hereditary diseases that are often underdiagnosed.
- Recent clinical evaluations at the ERN CRANIO center in Prague have highlighted various rare genetic disorders, including congenital cataract syndrome and non-syndromic deafness linked to specific genetic mutations.
- This study emphasizes the need for awareness and accurate diagnosis of dental issues that can aid in better treatment and management of these genetic conditions in the Czech Roma community.
Mammalian ω3- and ω6-PUFAs are synthesized from essential fatty acids (EFAs) or supplied by the diet. PUFAs are constitutive elements of membrane architecture and precursors of lipid signaling molecules. EFAs and long-chain (LC)-PUFAs are precursors in the synthesis of endocannabinoid ligands of G protein-coupled cannabinoid receptor (CB)1 and CB2 in the endocannabinoid system, which critically regulate energy homeostasis as the metabolic signaling system in hypothalamic neuronal circuits and behavioral parameters.
View Article and Find Full Text PDFCa flux into axon terminals via P-/Q-type Ca2.1 channels is the trigger for neurotransmitter vesicle release at neuromuscular junctions (NMJs) and many central synapses. Recently, an arginine to proline substitution (R1673P) in the S4 voltage-sensing helix of the fourth membrane-bound repeat of Ca2.
View Article and Find Full Text PDFObjectives: We sought to objectivize the overall alveolar bone thickness changes in lower incisors after orthodontic intervention.
Background: The effect of orthodontic treatment on the cortical bone, specifically the clinical implications of proclination-induced change, have long been a matter of dispute.
Methods: Cone-beam computed tomographs of 58 patients were obtained before and after treatment and labial cortical bone thickness and overall alveolus width were measured in sagittal sections in the distance of 3, 6, 9 and 12 mm apically from the cemento-enamel junction.
Aim: Constitutive release of NO blunts intrinsic and stimulated contractile activity in cerebral arteries (CA). Here, we explored whether phosphorylation and expression levels of the PKG-sensitive, leucine zipper positive (LZ ) splice variants of the regulatory subunit of myosin phosphatase (MYPT1) are involved and whether its expression is associated with higher cGMP sensitivity.
Methods: Vascular contractility was investigated by wire myography.