Publications by authors named "D Fietz"
Purpose: Sperm morphology and motility are major contributors to male-factor infertility, with many genes predicted to be involved. This study aimed to elucidate differentially expressed transcripts in human testis tissues of normal and abnormal spermatogenesis that could reveal new genes that may regulate sperm morphology and function.
Methods: Human testis biopsies were collected from men with well-characterized phenotypes of normal spermatogenesis, spermatid arrest, and Sertoli cell-only phenotype, and transcriptional differences were quantified by RNA-sequencing (RNA-Seq).
Imbalances in testicular iron levels are linked to compromised sperm production and male infertility. Iron regulatory proteins (IRP) 1 and 2 play crucial roles in cellular iron regulation. We investigated the role of IRP1 on spermatogenesis using Irp1-deficient mice (Irp1).
View Article and Find Full Text PDFSulfation pathways are an essential part of overall sulfur metabolism. Sulfation pathways are mainly about sulfate activation, and the making and breaking of biological sulfate esters. This special issue features some extended reflection on what was presented at the SUPA 2023 meeting on Sulfation Pathways.
View Article and Find Full Text PDFArticle Synopsis
- * The study reveals that interferon-epsilon (IFNε), found in specific cells within the testes, plays a crucial role in fighting viral infections in both mice and humans.
- * Mice without IFNε were more vulnerable to Zika virus damage, while adding IFNε to human testicular cells decreased viral presence and inflammation, indicating its importance in protecting male reproductive health.
Use of a slow-release GnRH implant in an adult billy goat.
Tierarztl Prax Ausg G Grosstiere Nutztiere
August 2024
Article Synopsis
- A special implant called deslorelin was put into a healthy male goat to see if it could make him temporarily infertile and reduce his sexual behavior.
- After 6 weeks, the goat's testicles didn't change in size, and there were no effects on his hormone levels.
- The goat's ability to produce sperm also stayed normal, showing that this implant didn't affect his fertility.