ANGPTL3 Deficiency and Risk of Hepatic Steatosis.

Background: ANGPTL3 (angiopoietin-like 3) is a therapeutic target for reducing plasma levels of triglycerides and low-density lipoprotein cholesterol. A recent trial with vupanorsen, an antisense oligonucleotide targeting hepatic production of ANGPTL3, reported a dose-dependent increase in hepatic fat. It is unclear whether this adverse effect is due to an on-target effect of inhibiting hepatic ANGPTL3.

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease.

Ceftriaxone is a beta-lactam antibiotic that increases the expression of the major glutamate transporter, GLT-1. As such, ceftriaxone ameliorates symptoms across multiple rodent models of neurological diseases and substance use disorders. However, the mechanism behind GLT-1 upregulation is unknown.

High-intensity focused ultrasound for prostate cancer.

High-intensity focused ultrasound (HIFU) is a noninvasive procedure that has shown promising results in a wide range of malignant and nonmalignant conditions, including localized prostate cancer (PCa). This review aims to describe the application of HIFU in the management of patients with PCa, explaining its basic therapeutic principles, going through the main phases during aHIFU session, and providing an overview of the main available pieces of evidence from literature. HIFU treatment for prostate cancer is increasingly performed with high success and safety.

Backwash sediment record of the 2009 South Pacific Tsunami and 1960 Great Chilean Earthquake Tsunami.

Following recent tsunamis, most studies have focused on the onshore deposits, while the offshore backwash deposits, crucial for a better understanding of the hydrodynamic processes during such events and offering an opportunity for sedimentary archives of past tsunamis, have mostly been omitted. Here, we present a unique sedimentary record of the backwash from two historical tsunamis sampled in a sheltered bay in American Samoa, namely the 2009 South Pacific Tsunami and the 1960 Great Chilean Earthquake Tsunami. Although not always concomitant with a marked grain size change, backwash deposits are identified by terrestrial geochemical and mineralogical signatures, associated with basal soft sediment micro-deformations.

DWI and PRECISE criteria in men on active surveillance for prostate cancer: A multicentre preliminary experience of different ADC calculations.

Purpose: The PRECISE score estimates the likelihood of radiological progression in patients on active surveillance (AS) for prostate cancer (PCa) with serial multiparametric magnetic resonance imaging (mpMRI). A PRECISE score of 1 or 2 denotes radiological regression, PRECISE 3 indicates stability and PRECISE 4 or 5 implies progression. We evaluated the inter-reader reproducibility of different apparent diffusion coefficient (ADC) calculations and their relationship to the PRECISE score.