The impact of genetic variability on Alzheimer's therapies: obstacles for pharmacogenetic progress.

Introduction: Genetic load influences the therapeutic response to conventional drugs in Alzheimer's disease (AD). Pharmacogenetics (PGx) is the best option to reduce drug-drug interactions and adverse drug reactions in patients undergoing polypharmacy regimens. However, there are important limitations that make it difficult to incorporate pharmacogenetics into routine clinical practice.

Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia.

Introduction: Acute undifferentiated febrile illnesses are fevers lasting less than fourteen days without an evident focus of infection on the initial physical examination or with inconclusive laboratory tests.

Objective: Carry out epidemiological surveillance of the etiology of acute undifferentiated febrile syndrome in the Meta department.

Methods: A descriptive, prospective cross-sectional study was carried out between February 2021 and June 2023 in a first-level hospital in the department of Meta, Colombia.

Nanoscale Titanium Oxide Memristive Structures for Neuromorphic Applications: Atomic Force Anodization Techniques, Modeling, Chemical Composition, and Resistive Switching Properties.

This paper presents the results of a study on the formation of nanostructures of electrochemical titanium oxide for neuromorphic applications. Three anodization synthesis techniques were considered to allow the formation of structures with different sizes and productivity: nanodot, lateral, and imprint. The mathematical model allowed us to calculate the processes of oxygen ion transfer to the reaction zone; the growth of the nanostructure due to the oxidation of the titanium film; and the formation of TiO, TiO, and TiO oxides in the volume of the growing nanostructure and the redistribution of oxygen vacancies and conduction channel.

Maternal Gestational Diabetes Mellitus (GDM) Moderates the Association Between Birth Weight and EEG Power in Healthy Term-Age Newborns.

Gestational diabetes mellitus (GDM) affects around 10% of pregnancies in the United States and has been linked to neurodevelopmental sequelae in children. However, there is a paucity of studies investigating early-life neural markers in GDM-exposed infants. This study examined the association of GDM with relative EEG power among healthy term-age neonates collected during natural sleep.