SLC6A4 gene variants moderate associations between childhood food insecurity and adolescent mental health.

Background: Food insecurity is a persistent concern in the United States and has been shown to affect child mental health and behavior. The SLC6A4 gene has been indicated as a moderator of the effects of chronic stress on anxiety in adolescents aged 14-21. However, it is unclear if SLC6A4 may also play a role in the effects of childhood food insecurity, a form of chronic stress, on adolescent mental health.

Synthesis and Characterization of Zinc(II) Complexes Bearing 4-Acridinol and 1-Phenazinol Ligands.

The synthesis and characterization of zinc(II) chelates bearing acridin-4-ol (), phenazin-1-ol (), and benzo[]phenazin-1-ol () are presented. The formation of homoleptic () or heteroleptic () products can be controlled by stochiometric or excess amounts of zinc(II) acetylacetonate monohydrate, Zn(acac), respectively. Electrochemical and photophysical studies show that the homoleptic complexes (, , and ) have ligand-centered properties inherited from the corresponding free ligands.

Prognostic impact of tumour burden in stage IV neuroendocrine neoplasia: A comparison between pancreatic and gastrointestinal localizations.

Background: Although prognosis of NENs is affected by several features including tumour burden, the specific role of this factor in pancreatic NENs (PanNENs) and gastrointestinal NENs (GI NENs) is not well established.

Aim: To compare the prognostic role of tumour burden in PanNENs and GI NENs.

Patients And Methods: This study was a retrospective analysis of stage IV PanNENs and GI NENs.

Effects of low-dose aspirin on clinical outcome and disease progression in patients with gastroenteropancreatic neuroendocrine neoplasm.

The chemopreventive effect of aspirin (ASA) has been observed in the setting of colorectal cancer and other solid neoplasms. Recently, ASA has demonstrated a promising anti-proliferative effect on GEP-NENs . However, the direct anti-neoplastic impact of ASA on GEP-NEN clinical outcome is yet to be clarified.