Photonic Topological Mode Bound to a Vortex.

We report the observation of a mode associated with a topological defect in the bulk of a 2D photonic material by introducing a vortex distortion to a hexagonal lattice analogous to graphene. The observed modes lie midgap at zero energy and are closely related to Majorana bound states in superconducting vortices. This is the first experimental demonstration of the Jackiw-Rossi model [R.

Quantum Refrigeration with Indefinite Causal Order.

We propose a thermodynamic refrigeration cycle which uses indefinite causal orders to achieve nonclassical cooling. The cycle cools a cold reservoir while consuming purity in a control qubit. We first show that the application to an input state of two identical thermalizing channels of temperature T in an indefinite causal order can result in an output state with a temperature not equal to T.

Using Bayesian methodology to explore the profile of mental health and well-being in 646 mothers of children with 13 rare genetic syndromes in relation to mothers of children with autism.

Background: It is well documented that mothers of children with intellectual disabilities or autism experience elevated stress, with mental health compromised. However, comparatively little is known about mothers of children with rare genetic syndromes. This study describes mental health and well-being in mothers of children with 13 rare genetic syndromes and contrasts the results with mothers of children with autism.

Effectiveness of Active Support for adults with intellectual disability in residential settings: Systematic review and meta-analysis.

Background: The review examined the effectiveness of Active Support (RQ1) and stakeholders' experiences of the model (RQ2).

Method: Data were meta-analysed (RQ1; studies = 14) and synthesized narratively (RQ2; studies = 10).

Results: By follow-up (6 months post-training), effect sizes (RQ1) for resident total activity engagement were significant and ranged from small (d = 0.

A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities.

Background: Data suggest that approximately 50,000 adults with learning disabilities (LDs) in England and Wales are currently prescribed antipsychotic medication. Illness in this population is common, including significant rates of challenging behaviour and mental illness, but there is particular concern over the use of antipsychotics prescribed for reasons other than the treatment of psychosis. Control of challenging behaviour is the primary reason why such medications are prescribed despite the absence of good evidence for any therapeutic effect for this purpose.