Publications by authors named "D Federico"
Background And Objective: Bladder cancer (BC) represents a significant health care challenge and is frequently detected during evaluations for haematuria in emergency departments (EDs). Our aim was to evaluate the clinical performance and economic implications of the Xpert BC Detection (BCD) test for patients presenting to the ED with haematuria to address the pressing need for more efficient and accurate diagnostic tools in this setting.
Methods: We conducted a prospective single-centre observational study in the ED of a tertiary university hospital.
Article Synopsis
- The study investigates the role of histone demethylase JMJD3 in the nucleus accumbens and its impact on heroin-seeking behavior after a period of abstinence in male rats.
- Findings show that JMJD3 levels and phosphorylated SMAD1/5 increase following 14 days of heroin abstinence, and manipulating these pathways affects drug-seeking behaviors.
- The research concludes that JMJD3 is involved in long-term changes linked to heroin relapse, with its effects being regulated by the bone morphogenetic protein (BMP) signaling pathway.
Palmoplantar (PP) psoriasis is considered one of the most hard-to-treat areas with important impact on patients' quality of life, and few data are available about the efficacy of dimethylfumarate (DMF) on these areas. In our noninterventional multicentre retrospective cohort study of patients with PP psoriasis treated with DMF, effectiveness was evaluated as mean pp Psoriasis Area and Severity Index (ppPASI) reduction and as proportion of patients that reach ppPASI 75 at 4, 12, 24 and 48 weeks. The reduction in ppPASI was 23.
View Article and Find Full Text PDFObjectives: To investigate the vascular networks of the retina and choroid using optical coherence tomography angiography (OCTA) to identify early biomarkers of obstructive sleep apnea (OSA) severity and to evaluate correlations with blood levels of oxidative stress.
Study Design: Patients with OSA were diagnosed based on video-polysomnography (PSG) and blood samples were collected to evaluate oxidative stress markers: total antioxidant status (TAS), biological antioxidant potential (BAP) test, Diacron reactive oxygen metabolites (d-ROMs) test. The eyes of children with OSA were evaluated and compared with eyes of healthy age-matched children.
Article Synopsis
- Patients with Alzheimer's disease and their caregivers are at a higher risk for medication-related issues due to aging and the use of multiple medications.
- A study assessed medication exposure among 73 pairs of Alzheimer's patients and their caregivers, revealing that patients used an average of 6.8 medications, while caregivers used 4.7, with a significant percentage of both groups taking potentially inappropriate medications (60.3% of patients and 47.9% of caregivers).
- The study highlights the importance of conducting medication reviews not only for patients but also for caregivers, as they are often overlooked in discussions about medication management.