Publications by authors named "D Fawkner-Corbett"
Article Synopsis
- Neonatal adrenal haemorrhage occurs in about 0.17%-0.21% of infants but is often asymptomatic, suggesting the actual rate may be higher due to underreporting.
- The condition is more likely in neonates because their adrenal glands are larger and more vascular, making them susceptible to bleeding, especially during labor.
- A case study describes a newborn with symptoms indicating bowel obstruction, where surgical exploration revealed that adrenal haemorrhage was the rare cause of the obstruction, highlighting the need to consider this diagnosis when similar symptoms arise.
The success of checkpoint inhibitors (CPIs) for cancer has been tempered by immune-related adverse effects including colitis. CPI-induced colitis is hallmarked by expansion of resident mucosal IFNγ cytotoxic CD8 T cells, but how these arise is unclear. Here, we track CPI-bound T cells in intestinal tissue using multimodal single-cell and subcellular spatial transcriptomics (ST).
View Article and Find Full Text PDFObjective: Possible childhood appendicitis is a common emergency presentation. The exact value of blood tests is debated. This study sought to determine the diagnostic accuracy of four blood tests (white cell count (WCC), neutrophil(count or percentage), C reactive protein (CRP) and/or procalcitonin) for childhood appendicitis.
View Article and Find Full Text PDFThe intestine has a large number of cell types. Thus, digestion of pure and viable populations is necessary for downstream techniques including single-cell RNA sequencing. We outline a protocol to isolate both epithelial and non-epithelial cells from human fetal samples at high viability, which was used to produce a full thickness atlas of intestinal cells across human development.
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