Implementation of indication-based antibiotic order sentences improves antibiotic use in emergency departments.

Introduction: Prior data have suggested that suboptimal antibiotic prescribing in the emergency department (ED) is common for uncomplicated lower respiratory tract infections (LRTI), urinary tract infections (UTI), and acute bacterial skin and skin structure infections (ABSSSI). The objective of this study was to measure the effect of indication-based antibiotic order sentences (AOS) on optimal antibiotic prescribing in the ED.

Methods: This was an IRB-approved quasi-experiment of adults prescribed antibiotics in EDs for uncomplicated LRTI, UTI, or ABSSSI from January to June 2019 (pre-implementation) and September to December 2021 (post-implementation).

Ouabain-induced changes in aqueous humour outflow facility and trabecular meshwork cytoskeleton.

Background: Inhibition of the Na,K-ATPase by ouabain results in decreased intraocular pressure (IOP), by mechanisms that are not completely understood. Cellular mechanisms that regulate aqueous humour outflow through the trabecular meshwork (TM) include changes in the TM cytoskeleton. Because inhibition of the Na,K-ATPase by ouabain alters the cell's cytoskeleton, the role of the ouabain in regulating aqueous humour outflow and TM cytoskeleton was investigated.

Evaluation of health, sanitation, and nutrition in Forces Command Child Development Centers.

In 1992, Forces Command had 42 Child Development Centers on 22 installations. We evaluated program compliance in the areas of health, sanitation, and nutrition using inspection findings from April 1991 through June 1992. Each program was rated on 20 items, using inspection checklists developed for this evaluation.