Coassembling Mesoporous Zeolitic Imidazolate Frameworks by Directed Reticular Chemistry.

Conventional microporous zeolitic imidazolate frameworks (ZIFs) face limitations in mass transfer and pore accessibility when dealing with large guest molecules. Here, we describe a technique for the synthesis of mesoporous ZIFs (MesoZIFs) using a strategy we term directed reticular chemistry. MesoZIF-8 was prepared through solvent evaporation-induced coassembly of polystyrene--poly(ethylene oxide) (PS--PEO), ZIF-8 building blocks, and acetic acid (AcOH), followed by amine-facilitated crystallization of ZIF-8 in the interstices of PS--PEO micelles.

Surface engineering of metal-organic framework nanoparticles-based miRNA carrier: Boosting RNA stability, intracellular delivery and synergistic therapy.

MicroRNAs (miRNAs) are small noncoding RNAs that are critical for the regulation of multiple physiological and pathological processes, thus holding great clinical potential. However, the therapeutic applications of miRNAs are severely limited by their biological instability and poor intracellular delivery. Herein, we describe a dual-layers surface engineering strategy to design an efficient miRNA delivery nanosystem based on metal-organic frameworks (MOFs) incorporating lipid coating.

Spin crossover {[Fe(atrz)](OTs)} monolith: a green synthesis approach for Robust switchable materials.

This work presents a straightforward, room-temperature synthesis of a robust {[Fe(atrz)](OTs)} monolith. This approach offers a green alternative to traditional nanoparticle synthesis for manipulating spin crossover (SCO) behaviour. The monolith exhibits a more gradual SCO transition at lower temperatures compared to the bulk material, aligning with observations in smaller particle systems.

Enhancing Drug Delivery Efficacy Through Bilayer Coating of Zirconium-Based Metal-Organic Frameworks: Sustained Release and Improved Chemical Stability and Cellular Uptake for Cancer Therapy.

The development of nanoparticle (NP)-based drug carriers has presented an exciting opportunity to address challenges in oncology. Among the 100,000 available possibilities, zirconium-based metal-organic frameworks (MOFs) have emerged as promising candidates in biomedical applications. Zr-MOFs can be easily synthesized as small-size NPs compatible with intravenous injection, whereas the ease of decorating their external surfaces with functional groups allows for targeted treatment.

Expanding the Reticular Chemistry Building Block Library toward Highly Connected Nets: Ultraporous MOFs Based on 18-Connected Ternary, Trigonal Prismatic Superpolyhedra.

The chemistry of metal-organic frameworks (MOFs) continues to expand rapidly, providing materials with diverse structures and properties. The reticular chemistry approach, where well-defined structural building blocks are combined together to form crystalline open framework solids, has greatly accelerated the discovery of new and important materials. However, its full potential toward the rational design of MOFs relies on the availability of highly connected building blocks because these greatly reduce the number of possible structures.