Cancer-related financial hardship (i.e., financial toxicity) has been associated with anxiety and depression, greater pain and symptom burden, treatment nonadherence, and mortality.
View Article and Find Full Text PDFFrontotemporal dementia (FTD) is a neurodegenerative disease with a strong genetic basis. Understanding the structural brain changes during pre-symptomatic stages may allow for earlier diagnosis of patients suffering from FTD; therefore, we investigated asymptomatic members of FTD families with mutations in and granulin () genes. Clinically asymptomatic subjects from families with mutation (15 mutation carriers, +; and 23 non-carriers, -) and mutations (9 mutation carriers, +; and 15 non-carriers, -) underwent structural neuroimaging (MRI).
View Article and Find Full Text PDFAlzheimers Dement (Amst)
September 2015
Introduction: Freely accessible online tests for the diagnosis of Alzheimer's disease (AD) are widely available. The objective of this study was to evaluate these tests along three dimensions as follows: (1) scientific validity; (2) human-computer interaction (HCI) features; and (3) ethics features.
Methods: A sample of 16 online tests was identified through a keyword search.
J Int Neuropsychol Soc
August 2014
Mutations in the progranulin gene (GRN) are a common cause of familial frontotemporal dementia. We used a comprehensive neuropsychological battery to investigate whether early cognitive changes could be detected in GRN mutation carriers before dementia onset. Twenty-four at-risk members from six families with known GRN mutations underwent detailed neuropsychological testing.
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