Publications by authors named "D F Winn"
Background: Tranexamic acid (TXA) is a promising active to treat hyperpigmentation disorders, such as melasma and acne scars. However, TXA is highly hydrophilic and its penetration into the skin is poor and formulation dependent.
Aims: In this study, our aim was to evaluate the in vivo skin penetration of an ester-modified TXA, TXVector, directly on the skin of volunteers.
Article Synopsis
- - Drowning is the leading cause of accidental death for California kids under five, with an average of 49 fatalities per year from 2010-2021, despite the California Pool Safety Act aimed at reducing these numbers.
- - A study from 2017-2021 found 4,166 drowning incidents in children aged 1-4, including 234 fatalities, but no significant change in fatality rates over the five years was noted.
- - Pool drownings accounted for 65% of fatal incidents, highlighting the need for better data collection on risk factors to enhance prevention efforts and decrease drowning rates among young children.
Objective: To assess whether a two-phase intervention was associated with improvements in antibiotic prescribing among nonhospitalized children with community-acquired pneumonia.
Study Design: In a large health care organization, a first intervention phase was implemented in September 2020 directed at antibiotic choice and duration for children 2 months through 17 years of age with pneumonia. Activities included clinician education and implementation of a pneumonia-specific order set in the electronic health record.
Preclinical transplantations using human neuroepithelial stem (NES) cells in spinal cord injury models have exhibited promising results and demonstrated cell integration and functional improvement in transplanted animals. Previous studies have relied on the generation of research grade cell lines in continuous culture. Using fresh cells presents logistic hurdles for clinical transition regarding time and resources for maintaining high quality standards.
View Article and Find Full Text PDFObjectives: This analysis examined the clinical and histopathological characteristics of white and red oral mucosal lesions and patient lifestyle behaviors to understand how the lesions changed over 19-23 years, including among patients who developed oral and pharyngeal cancer.
Materials And Methods: Seventy-five individuals with red and/or white oral mucosal lesions with clinical diagnoses of smokeless tobacco lesions, leukoplakia, erythroplakia, lichen planus, ulcer, and virus-associated lesions were identified in six Veterans Affairs Medical Center Dental Clinics (VAMC) from 1996 to 2001. Biopsy results and patients' sociodemographic, medical, and tobacco/alcohol use characteristics were obtained.