Publications by authors named "D F Vacca"
: The main aim of this study is to analyze the outcomes of NSTEMI admissions and test the relevance of TIMI as a risk score in a real-world setting. We also examine any potential social or health care disparities involved with outcomes of NSTEMI admissions. This study also investigates factors associated with mortality in NSTEMI admissions and its correlation with heart catheterization during admission.
View Article and Find Full Text PDFBackground/objectives: The aim of this study is to analyze the difference in hospital outcomes for infective endocarditis (IE) admissions with and without comorbid congestive heart failure (CHF).
Methods: The National Inpatient Sample (NIS) was the database we used to find and sort patient data from inpatient hospitalizations. We then used logit probit regression to analyze the association between patients admitted for IE with and without CHF and their all-cause mortality rates.
Article Synopsis
- Eosinophils, when activated by the alarmin IL-33, produce extracellular vesicles (EV) that show potential anti-tumor effects, contrasting with those activated by IL-5.
- Incorporating these IL-33-activated eosinophil-derived EV (Eo33-EV) into tumor cells leads to increased expression of genes that promote cell cycle arrest and reduces tumor growth and metastasis.
- RNA sequencing highlights that Eo33-EV are enriched with tumor suppressor genes and pathways that enhance an epithelial phenotype, indicating their potential role in cancer therapy through cell reprogramming.
Article Synopsis
- The study investigates the distinct regions of the germinal center (GC)—the dark zone (DZ) and light zone (LZ)—which are crucial for B-cell expansion and antibody maturation, yet lack a clear understanding of their immune composition differences.
- Researchers discovered specific DNA damage responses and chromatin features that explain why T-cells are excluded from the DZ region, providing insights into its immune-repulsive characteristics.
- The findings highlight the role of the ATR kinase in regulating responses in the DZ, suggesting that targeting ATR could enhance immunotherapy effectiveness for aggressive types of lymphoma like Diffuse Large B-cell Lymphomas (DLBCL).