Trend Analysis by Risk Observation: How the German Statutory Accident Insurance Prepares for the Future in Occupational Safety and Health.

Background: The risk observatory (RO) of the German Social Accident Insurance (DGUV) provides strategic support to the German Social Accident Insurance Institutions (GSAII) in proactive prevention. It does so by identifying future challenges and opportunities for occupational safety and health (OSH) resulting from new trends and developments that affect employees as well as children in elementary education, pupils, and students.

Methods: The core of the RO is an online survey that relies on a pool of new trends and developments identified via internet and literature research.

The pan-immune-inflammation value and systemic immune-inflammation index in advanced melanoma patients under immunotherapy.

Purpose: To evaluate the pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII) in patients with cutaneous melanoma (CM) under immune checkpoint inhibitor (ICI) therapy.

Methods: PIV and SII were calculated before the start of ICI therapy and at time of progression/death in patients with metastatic CM (stage III/IV). Sex-age-matched CM patients in stage I/II and healthy subjects (HC) served as controls.

Volume increase of spleen in melanoma patients undergoing immune checkpoint blockade.

To find out whether treatment with immune checkpoint inhibitors (ICIs) results in volume increase of the spleen. We studied 49 stage III and IV melanoma patients with an indication for ICIs. Computer tomographic-assisted volumetry of spleens was performed.

Usability Design in Medical Informatics: A Prospective Research Project.

This short paper aims to raise awareness of good usability design in medical computer sciences. We present a research plan about developing usability design guidelines for web application development in medical informatics. Following a nimble creation process we shall create a guideline tailored for software developers, that aims to improve communication between the developer and the medical professional.