Publications by authors named "D F Perrault"
In this study, we present the first-in-human use of topical deferoxamine (DFO) in the treatment of a beta-thalassemia wound. We elected to use DFO on a patient that suffered from a chronic nonhealing wound in the setting of beta-thalassemia. Despite approximately 55 weeks of marginal improvement in healing, this patient's wound healed completely after 21 weeks of treatment with DFO.
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- Orbital compartment syndrome is a serious but not well-understood issue in patients with acute burns, prompting a systematic review to examine its risk factors and management approaches.
- The review analyzed 303 articles, with only 8 qualifying for深入 analysis; these were all retrospective studies indicating that this syndrome commonly arises within 24 hours after a burn injury.
- The study highlights that a rise in intraocular pressure above 30-40 mmHg is critical for diagnosis, and surgical intervention typically begins with a lateral canthotomy, with varying quality scores indicating the need for better-established guidelines in treatment.
Article Synopsis
- Epidermolysis bullosa is a genetic skin disorder that leads to blister formation due to mechanical trauma, with dystrophic epidermolysis bullosa (DEB) being a severe form caused by COL7A1 gene mutations.
- DEB presents symptoms like blisters from birth, extensive scarring, and deformities such as "mitten hand" from skin fusion.
- Current treatments are mainly supportive, but new therapies, including gene therapy (like B-VEC) and advanced skin grafts, show promise for improving patient outcomes, especially in treating pseudosyndactyly.
Small animals do not replicate the severity of the human foreign-body response (FBR) to implants. Here we show that the FBR can be driven by forces generated at the implant surface that, owing to allometric scaling, increase exponentially with body size. We found that the human FBR is mediated by immune-cell-specific RAC2 mechanotransduction signalling, independently of the chemistry and mechanical properties of the implant, and that a pathological FBR that is human-like at the molecular, cellular and tissue levels can be induced in mice via the application of human-tissue-scale forces through a vibrating silicone implant.
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