Publications by authors named "D F Lionello"
Synthesis, crystal structure and Hirshfeld surface analysis of sulfamethoxazolium methyl-sulfate monohydrate.
Acta Crystallogr E Crystallogr Commun
September 2024
The mol-ecular salt sulfamethoxazolium {or 4-[(5-methyl-1,2-oxazol-3-yl)sulf-amo-yl]anilinium methyl sulfate monohydrate}, CHNOS·CHOS·HO, was prepared by the reaction of sulfamethoxazole and HSO in methanol and crystallized from methanol-ether-water. Protonation takes place at the nitro-gen atom of the primary amino group. In the crystal, N-H⋯O hydrogen bonds (water and methyl-sulfate anion) and inter-molecular N-H⋯N inter-actions involving the sulfonamide and isoxazole nitro-gen atoms, link the components into a tri-dimensional network, additional cohesion being provided by face-to-face π-π inter-actions between the phenyl rings of adjacent mol-ecules.
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- Tioconazole has poor solubility in water, limiting its effectiveness as an antifungal, prompting research into new crystalline salts to enhance its bioavailability.
- Four new salts were created (mesylate, tosylate, maleate, and fumarate), with studies showing they have improved thermal stability and dissolution rates compared to the original free base and existing oxalate salt.
- The new salts, particularly the sulfonic acid derivatives, showed significantly better solubility at pH 4.3, indicating their potential as more effective alternatives for delivering tioconazole in various applications.
Article Synopsis
- Tioconazole has low solubility, which affects its effectiveness as an antifungal, prompting researchers to create a hydrochloride salt to improve its bioavailability.
- Single crystals of the new salt were grown and analyzed using various methods, including X-ray diffraction and thermal analysis, to confirm their structure and properties.
- The new salt demonstrated a dissolution rate over 2000 times faster than the original tioconazole, indicating potential for better solubility and effectiveness in medical applications.
Nifurtimox (NFX) is a nitrofuran derivative used to treat Chagas disease, a neglected disease caused by the protozoan Trypanosoma cruzi. The drug is very sparingly soluble in aqueous media and no other solid phases of NFX have been reported to date. The preparation of the amorphous mode of NFX is reported, as well as its characterization by hot stage microscopy, thermal (differential scanning calorimetry and thermogravimetric analysis), spectroscopic (solid state nuclear magnetic resonance, mid-infrared, and near-infrared), diffractometric and functional (powder dissolution rate) means.
View Article and Find Full Text PDFMain group element coordination polymers (MGE-CPs) are important compounds for the development of multifunctional materials. However, there has been a shortage of studies regarding their structural, optical, catalytic, mechanical, and antibacterial properties. This work presents an exhaustive study of a set of crystalline MGE-CPs obtained from bismuth and indium metals and iminodiacetate, 1,2,4,5-benzenetetracarboxylate, and 2,2'-bipyridine as building blocks.
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