Publications by authors named "D F Hoffmann"
Aims: Concerns over population-level immunity have been heightened with each successive wave of COVID-19, prompting questions about whether it is primarily derived from vaccination efforts or from previous natural infections with the virus. We wished to determine the seroprevalence of SARS-CoV-2 antibodies among healthcare workers (HCWs) in Pretoria (Tshwane), South Africa, and to establish whether they were derived from vaccination or natural infection.
Methods: Serum samples were collected from HCWs during the fourth wave of COVID-19 between 1 December 2021 and 13 March 2022.
Hypothetical axions provide a compelling explanation for dark matter and could be emitted from the hot solar interior. The CERN Axion Solar Telescope has been searching for solar axions via their back conversion to x-ray photons in a 9-T 10-m long magnet directed toward the Sun. We report on an extended run with the International Axion Observatory pathfinder detector, doubling the previous exposure time.
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- The widespread use of smartphones has led to the development of innovative telemedicine solutions, especially for SARS-CoV-2 PCR testing during the COVID-19 pandemic, which requires contactless healthcare.
- This feasibility study compared traditional healthcare professional-performed testing with a telemedicine-guided self-sampling approach, focusing on practicality, user satisfaction, and economic implications.
- Results showed high user satisfaction in the telemedicine group, with 76% returning samples, higher test completion rates than the conventional group, but at a slightly increased cost; the study indicates the potential for effective data sharing through a mobile app.
Background: Epstein-Barr virus (EBV)+ and EBV- primary CNS lymphomas (PCNSL) carry distinct mutational landscapes, but their transcriptional and epigenetic profiles have not been integrated and compared. This precludes further insights into pathobiology and molecular differences, relevant for classification and targeted therapy.
Methods: 23 EBV- and 15 EBV+ PCNSL, histologically classified as diffuse large B-cell lymphomas, were subjected to RNA-Sequencing and EPIC methylation arrays.