Publications by authors named "D F Beloyartsev"
Among the numerous driving forces that cause the atherosclerotic cardiovascular disease (ASCVD), pathogenic bacterial extracellular membrane nanovesicles (BEMNs) containing toxins and virulence factors appear to be the key trigger of inflammation and atherogenesis, the major processes involved in the pathogenesis of ASCVD. Since BEMNs are the carriers of nanosized biomolecules to distant sites, they are now being considered as a novel drug delivery system. Nowadays, many therapeutic strategies are used to treat ASCVD.
View Article and Find Full Text PDFLipase maturation factor 1 is an endoplasmic reticulum-resident transmembrane protein, which acts as a critical chaperone necessary for the folding, dimerisation, and secretion of lipases. In this review, we summarise data about the recently revealed role of lipase maturation factor 1 in endoplasmic reticulum redox homeostasis, its novel interaction partners among oxidoreductases and lectin chaperones, and the identification of fibronectin and the low-density lipoprotein receptor as novel non-lipase client proteins of lipase maturation factor 1. Additionally, the role of lipase maturation factor 1-derived circular RNA in atherosclerosis progression via the miR-125a-3p/vascular endothelial growth factor A\Fibroblast Growth Factor 1 axis is discussed.
View Article and Find Full Text PDFActivated neutrophils release neutrophil extracellular traps (NETs), complex structures composed of extracellular genetic material and proteins sourced from the nucleus, granules, and cytoplasm in response to pathogenic inflammatory conditions. These NETs play a crucial role in the host's innate immune defense against invasive infections. Notably, in conditions like atherosclerosis, these extracellular formations can also be elicited by inflammatory stimuli such as lipids, prothrombotic factors, platelet aggregation, or proinflammatory cytokines.
View Article and Find Full Text PDFVitamin D in Primary Sjogren's Syndrome (pSS) and the Identification of Novel Single-Nucleotide Polymorphisms Involved in the Development of pSS-Associated Diseases.
Diagnostics (Basel)
September 2024
Article Synopsis
- * Recent research has identified specific genetic markers (SNPs) that are linked to SS severity and related health complications, emphasizing the role of both the immune system and environmental triggers like viral infections.
- * There is emerging interest in the role of vitamin D in managing immune responses in SS patients, suggesting future research should explore genetic testing and personalized treatments to improve management strategies.
Article Synopsis
- - Systemic lupus erythematosus (SLE) is an autoimmune disorder mostly affecting young women, with causes linked to genetics, environmental influences, and pathogen interactions that disrupt immune function and lead to chronic inflammation.
- - Mitochondria are key players in SLE development as they regulate energy production, reactive oxygen species (ROS) levels, and cell death pathways; their dysfunction contributes to immune dysregulation and increased inflammation in immune cells.
- - Targeting mitochondrial function with drugs like sirolimus and N-acetylcysteine shows promise in treating SLE by restoring mitochondrial health, reducing oxidative stress, and improving immune responses, as evidenced by positive results in clinical and preclinical studies.