Publications by authors named "D Ethan Kahn"
Objective: Circulating lipids are linked with insulin resistance and increased cardiovascular disease risk. We previously reported that dihydroceramides, a specific type of sphingolipid, are elevated in insulin-resistant individuals; however, little is known regarding whether insulin-sensitizing lifestyle interventions can improve profiles of sphingolipids and other lipid species.
Methods: A total of 21 individuals with obesity participated in a 3-month lifestyle intervention of combined weight loss and exercise training.
Article Synopsis
- Peripancreatic adipose tissue (PAT), which accumulates with obesity, negatively affects metabolic health and beta cell function, highlighting its significance compared to subcutaneous adipose tissue (SAT).
- PAT secretes higher levels of inflammatory substances and certain adipokines linked to poor metabolic outcomes, with variations in islet insulin secretion observed between male and female donors.
- RNA sequencing reveals that PAT influences gene transcription and lipid metabolism in islets in a sex-dependent manner, suggesting different metabolic impacts compared to SAT.
Purpose: Diet/nutrition is the first-line non-pharmacological therapy in the treatment of diabetes. Diet/nutrition counseling is infrequently provided by primary care providers (PCPs), who have limited nutrition education in both medical and advanced practice provider curricula. This quality improvement project aimed to improve knowledge and attitude, and frequency of diet/nutrition counseling by PCPs among patients with uncontrolled diabetes (glycosylated hemoglobin A1c ≥8%), by providing an online continuing medical education (CME) program on diabetes diet/nutrition.
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