Publications by authors named "D Ertl"
Predicting phenotypes from a combination of genetic and environmental factors is a grand challenge of modern biology. Slight improvements in this area have the potential to save lives, improve food and fuel security, permit better care of the planet, and create other positive outcomes. In 2022 and 2023 the first open-to-the-public Genomes to Fields (G2F) initiative Genotype by Environment (GxE) prediction competition was held using a large dataset including genomic variation, phenotype and weather measurements and field management notes, gathered by the project over nine years.
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- - Predicting how genetic and environmental factors influence traits (phenotypes) is a critical challenge in biology, with potential benefits like improved health, food security, and environmental care.
- - The Genomes to Fields (G2F) initiative hosted a competition in 2022 and 2023, inviting global participants from various disciplines to develop models using a comprehensive dataset gathered over nine years, including genetic and environmental data.
- - Winning methods combined machine learning with traditional breeding techniques, showcasing a variety of approaches such as quantitative genetics and deep learning, indicating that no single strategy was universally superior in predicting phenotypes in this context.
Article Synopsis
- The study compared the effects of growth hormone therapy on children with growth hormone deficiency (GHD) and those born small for their gestational age (SGA), revealing significant differences in growth outcomes.
- After one year of therapy, children with GHD showed a greater increase in height compared to those with SGA, and this trend continued at their final height.
- The research indicated that short-term height increases were predictive of long-term growth outcomes in GHD patients, but not in SGA patients, suggesting differing responses to growth hormone therapy between these groups.
Article Synopsis
- The paper emphasizes the need for simultaneous advancements in genomics (measuring genetic variation) and phenomics (measuring trait variation) for agricultural populations to improve agricultural productivity.
- It discusses the Agricultural Genome to Phenome Initiative (AG2PI) and its efforts to coordinate with government agencies and stakeholders to improve agricultural outcomes through research collaboration.
- A workshop was held to identify challenges and innovation opportunities in AG2P research, resulting in a vision for future advancements and six specific goals for immediate implementation.
Objectives: The aim of this project was to develop a rectal formulation of metyrapone suitable for application in an infant hospitalised with McCune-Albright syndrome (MAS)-related Cushing syndrome and to provide a detailed description of the formulation protocol including quality control parameters.
Methods: Suppositories with a drug load of up to 100 mg metyrapone were prepared. Mass variation, content uniformity and drug release were analysed according to the guidelines set out by the European Pharmacopoeia.