Publications by authors named "D Epstein"
Introduction: The Voluntary Interruption of Pregnancy (IVE) law 27.610, enacted in 2020, urges healthcare providers to guarantee this practice. Previous investigations at the Hospital Italiano de Buenos Aires (HIBA) revealed that the lack of clear institutional protocols hindered the management of abortion.
View Article and Find Full Text PDFRegulatory perspectives on post-market evidence generation schemes for high-risk medical devices: a systematic review.
Expert Rev Pharmacoecon Outcomes Res
December 2024
Introduction: The new European Medical Device Regulation has raised the bar for the clinical evaluation of medical devices to gain marketing authorization by Notified Bodies (NBs) regarding certificates of conformity in Europe. Restrictions applied for High-risk medical devices (HRMD) may require further evidence generation. Some other jurisdictions apply similar schemes that may be useful to the European Union.
View Article and Find Full Text PDFArticle Synopsis
- Combat casualty care has improved due to evidence-based protocols, with a study comparing prehospital care and outcomes of patients from conflicts in 2014 and 2023 in southern Israel.
- The study found that the number of evacuated patients increased significantly from 251 in 2014 to 940 in 2023, while the time to hospital arrival decreased.
- There was an increase in the proportion of severely injured patients, a decrease in some advanced prehospital interventions, and an increase in prehospital blood transfusions, but in-hospital mortality rates remained stable across both conflicts.
Background: Crystalloid administration during early resuscitation of bleeding trauma patients is recommended by current guidelines, yet evidence supporting this practice is limited. We aimed to evaluate the trends in the utilization of crystalloids during the last decade and to determine the threshold crystalloid volume independently associated with mortality risk in trauma patients at risk of or experiencing shock.
Methods: A retrospective cohort study using data from the Israel National Trauma Registry (January 2013 to December 2022) was conducted.
Article Synopsis
- Developmental gene regulation relies on long-range communication between enhancers and promoters, which is not fully understood without considering the surrounding chromatin.
- Researchers studied the Sonic hedgehog (Shh) regulatory region in mouse brains to understand its structural configurations, discovering that it often maintains a compact form that can adopt various layouts regardless of Shh expression.
- They found that long-range enhancer-promoter interactions occur through both dependent and independent mechanisms of Shh expression, involving specific binding sites and active enhancers, leading to a proposed model that coordinates gene expression patterns.