Publications by authors named "D Enlander"
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a neuro-immune disease of uncertain pathogenesis. Human parvovirus B19 infection has been shown to occur just prior to development of the onset of CFS/ME in several cases, although B19 seroprevalence studies do not show any significant differences between CFS/ME and controls. In this study, we analysed parvovirus B19 markers in CFS/ME patients (n=200), diagnosed according to Fukuda CDC criteria, and normal blood donors (n=200).
View Article and Find Full Text PDFBackground: The authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) based on expression of 88 human genes.
Aim: To attempt to reproduce these findings, determine the specificity of this signature to CFS/ME, and test for associations between CFS/ME subtype and infection.
Methods: Expression levels of 88 human genes were determined in blood of 62 new patients with idiopathic CFS/ME (according to Fukuda criteria), six patients with Q-fever-associated CFS/ME from the Birmingham Q-fever outbreak (according to Fukuda criteria), 14 patients with endogenous depression (according to DSM-IV criteria) and 29 normal blood donors.
Article Synopsis
- - Researchers investigated gene expression abnormalities in the blood of 25 patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) compared to 50 healthy individuals, using advanced microarray technology.
- - They identified 88 genes with significant changes in expression, with 85 genes being upregulated and 3 downregulated, focusing on functions related to immune response and hematological diseases.
- - Further analysis of the gene expression data revealed 7 distinct subtypes of CFS/ME patients, each showing different clinical features and severity, suggesting a complex pathology of the disease.