Publications by authors named "D Engler"

Background: Atrial fibrillation is associated with cognitive dysfunction. Atrial cardiomyopathy has been correlated with both entities. We aimed to characterize the association of echocardiographic parameters of atrial cardiomyopathy with cognitive function and cerebral changes.

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Article Synopsis
  • A budget impact analysis was conducted to compare the costs of current treatment strategies with a new approach for population screening of atrial fibrillation (AF) in 75-year-olds across eight European countries.
  • The analysis showed that while AF screening leads to increased initial costs due to higher drug and screening expenses, it ultimately results in savings from reduced stroke-related costs.
  • The net budget impact of implementing AF screening varied by country, ranging from €10 in Ireland to €122 in the Netherlands, demonstrating the overall financial benefit of the screening despite the upfront costs.
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Individuals with subclinical atrial fibrillation (AF) face an increased risk of thromboembolic events, which may potentially be mitigated through AF screening and subsequent anticoagulation. However, data from randomized clinical trials (RCTs) indicate a lower stroke risk in subclinical AF compared with the clinical phenotype. This-along with the inherent bleeding risk related to anticoagulation-seems to render the net clinical benefit of AF screening less evident.

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Antimicrobial resistance (AMR) is being increasingly seen as the next pandemic due to high morbidity and mortality rates, with Sub-Saharan Africa currently having the highest mortality rates driven by high rates of inappropriate prescribing in ambulatory care. In South Africa, nurses typically provide a range of services, including prescribing, in public ambulatory care clinics. However, little is currently known about the perception of final-year nursing students regarding antibiotic use, AMR, and antimicrobial stewardship (AMS).

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