Publications by authors named "D Eckert"
Background: Low-dose morphine may be prescribed to reduce chronic breathlessness in chronic obstructive pulmonary disease (COPD). Recent subjective findings suggest morphine may influence breathlessness through sleep-related mechanisms. However, concerns exist regarding opioid safety in COPD.
View Article and Find Full Text PDFFLASH Bragg-Peak Irradiation With a Therapeutic Carbon Ion Beam: First In Vivo Results.
Int J Radiat Oncol Biol Phys
November 2024
Purpose: In recent years, ultra-high dose rate (UHDR) irradiation has emerged as a promising innovative approach to cancer treatment. Characteristic feature of this regimen, commonly referred to as FLASH effect, demonstrated primarily for electrons, photons, or protons, is the improved normal tissue sparing, whereas the tumor control is similar to the one of the conventional dose-rate (CDR) treatments. The FLASH mechanism is, however, unknown.
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- * It involves 140 participants aged 60 and older with untreated OSA, randomizing them into two groups: one receiving CPAP along with usual care for fall prevention, and the other receiving only the usual care.
- * The study will assess various outcomes including fall risk scores, gait, and overall health, with results intended for publication and future guidelines on fall prevention in older adults.
Article Synopsis
- Most research on precision medicine for obstructive sleep apnea (OSA) focuses on sleep parameters, but this study highlights the importance of wakefulness physiology measures for predicting OSA therapies.
- The study investigated the relationship between awake ventilatory control and OSA endotypes, analyzing data from a trial comparing morphine and placebo effects on OSA severity.
- Findings showed that awake chemosensitivity correlates with critical airway pressures and can predict changes in OSA severity when administered morphine, suggesting awake measures could enhance understanding of OSA physiology.
Juvenile idiopathic arthritis (JIA) is the most prevalent pediatric rheumatic disease. While disease-modifying antirheumatic drugs (DMARDs), especially biologics, have greatly transformed the management of JIA, there remain some unmet medical needs that require new treatment options. The objective of this work was to describe and apply a modeling and simulation approach to extrapolate upadacitinib efficacy from the adult diseases, rheumatoid arthritis (RA) and psoriatic arthritis (PsA), to their respective pediatric diseases, polyarticular course JIA (pcJIA), and juvenile PsA (JPsA).
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