Publications by authors named "D Ece"
Current guidelines recommend computed tomography (cCT) scans of the chest in children with leukemia following 96 h of the onset of idiopathic neutropenia to eliminate pulmonary invasive fungal infections (IFIs). However, cCT exposes some children who are at a very high risk of developing secondary cancers to radiation. We aimed to determine the effect of antifungal prophylaxis (AFP) with voriconazole (VCZ) on the need for cCT scans in children with acute lymphoblastic leukemia (ALL) to eliminate pulmonary IFIs during chemotherapy.
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- Mediastinal lymphadenopathy with high 18-fluorodeoxyglucose uptake after lung cancer surgery may indicate recurrence, but can also result from foreign body reactions due to previously placed oxidized cellulose.
- A study evaluated 34 lung cancer patients post-surgery using EBUS-TBNA, classifying outcomes as metastasis, foreign body reaction, or reactive lymph nodes.
- Results showed that foreign body reactions were relatively common, characterized by an earlier presentation and lower maximum standardized uptake values (SUVMax) compared to metastasis.
Article Synopsis
- - Chronic myeloid leukemia (CML) is rare in children, but treatment with tyrosine kinase inhibitors (TKI) has shown excellent survival rates, with all patients in the study responding positively within 20 to 68 days of starting treatment.
- - A review of 15 pediatric patients treated from 1997 to 2022 revealed that 100% of them survived, with significant responses seen within 6 months for some, and a median follow-up of 79 months.
- - The study suggests that while most patients can maintain remission and continue TKI treatment for several years, some can safely stop the medication without experiencing a relapse, indicating a promising outlook for children with chronic phase CML.
Article Synopsis
- CMV infections are common in young patients with acute lymphoblastic leukemia (ALL) in Turkey, with 90.11% being seropositive at diagnosis and a 70.34% infection rate during treatment.
- Reactivation of CMV is more prevalent than new infections, and seropositivity at diagnosis strongly predicts future CMV infections.
- Close monitoring for CMV levels is crucial, as even low levels can lead to complications, emphasizing the need for careful management in immunosuppressed pediatric patients.