Publications by authors named "D E Wrede"
Article Synopsis
- The study investigates the use of automated image analysis for assessing microcirculation during major surgeries, specifically comparing it to a well-established manual analysis method to see how accurately it measures microcirculatory parameters.* -
- Researchers recorded sublingual microcirculation videos from patients at various stages around surgery, analyzing a total of 336 videos and assessing the agreement between the automated and manual analysis methods through statistical measures.* -
- Results indicated poor agreement between the two analysis methods, suggesting that the automated system is not reliable for clinical use, indicating the need for further development or improvement in the automated technology.*
Epigenetics generally involves genetic control by factors other than our own DNA sequence. Recent research has focused on delineating the mechanisms of two major epigenetic phenomena: DNA methylation and histone modification. As epigenetics involves many cellular processes, it is no surprise that it can also influence disease-associated gene expression.
View Article and Find Full Text PDFContext: Body weight and composition may change over the natural menopause transition. Whether surgical menopause has similar effects, and the impact of hormone replacement therapy (HRT), are unknown. Understanding the metabolic effects of surgical menopause will inform clinical care.
View Article and Find Full Text PDFOrbital atherectomy for calcified femoropopliteal lesions: a current review.
J Cardiovasc Surg (Torino)
April 2019
The orbital atherectomy system is a novel form of atherectomy that uses orbital sanding and pulsatile forces, an effective method of treatment for peripheral atherosclerotic lesions with varying levels of occlusion. Although the devices only has a general indication from the FDA to treat atherosclerotic lesions, they are effective in treating all kinds of lesions, and can therefore mitigate effects of all severities of peripheral artery disease. This approach to endovascular therapy involves the use of differential sanding to preferentially ablate fibrous, fibrofatty and calcified lesions, while deflecting healthy intima away from the crown.
View Article and Find Full Text PDFBackground: Coronary bifurcation and calcified lesions account for 15-20% and 6%-20% of percutaneous coronary interventions (PCI), respectively. Treatment of these lesions is associated with high periprocedural complication rates and unfavorable long-term clinical outcomes, including high rates of revascularization. This retrospective, single-center study evaluated the outcomes of atherectomy treatment for heavily calcified coronary bifurcation lesions.
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