Publications by authors named "D E Wilder"

It is well documented that service members are exposed to repeated low-level blast overpressure during training with heavy weapons such as artillery, mortars and explosive breaching. Often, acute symptoms associated with these exposures are transient but cumulative effect of low-level repeated blast exposures (RBEs) can include persistent deficits in cognitive and behavioral health. Thus far, reliable diagnostic biomarkers which can guide countermeasure strategies have not been identified.

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Introduction: Blast injury has been implicated as the major cause of traumatic brain injury (TBI) and ocular system injury, in military operations in Iraq and Afghanistan. Soldiers exposed to traumatic stress also have undiagnosed, chronic vision problems. Here we hypothesize that excessive intake of ω-6 fatty acid linoleic acid (LA) and insufficiency of dietary long chain ω-3 polyunsaturated fatty acids (PUFAs, e.

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Modern medical training consists largely of lecture-based instruction and in vivo or video modeling of specific skills. Other instructional methods, such as teaching with acoustical guidance (TAGteach), have rarely been evaluated. In this study, we compared teaching with tactile guidance, or tactile TAGteach in which a vibratory stimulus is delivered to indicate a correct response, with video modeling and self-evaluative video feedback to teach four participants two medical skills: simple interrupted suture and endotracheal intubation.

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Article Synopsis
  • Blast-related traumatic brain injury (bTBI) is a significant neurological issue for military personnel, leading to long-term health problems and impacts on quality of life, with varying manifestations that complicate understanding.
  • Research into blast injuries has shifted from rodent models to ferrets, as their brain structure more closely resembles that of humans, allowing for better insights into the effects of bTBI.
  • Findings from this study on ferrets exposed to blasts revealed issues like impulsivity in decision-making, increased glutamate levels linked to behavioral deficits, high levels of brain -acetylaspartate indicating potential metabolic disruptions, and pre-frontal cortex/auditory cortex signaling dysfunction that may relate to psychiatric disorders.
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Article Synopsis
  • Blast exposure leads to significant auditory deficits, particularly affecting central auditory processing, which is not well understood compared to effects on the ear itself.
  • The study investigated how blast injuries impaired synaptic connectivity in the auditory cortex of mice using various techniques such as electrophysiology and proteomic analysis.
  • Results showed immediate functional connectivity issues and structural changes in the auditory cortex that began to recover within weeks, highlighting potential targets for therapy to improve hearing in blast-exposed patients.
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