Publications by authors named "D E Wedge"
Article Synopsis
- Normal tissues adjacent to breast tumors (NATs) may contain early signs of breast cancer development due to a phenomenon called field cancerization.
- A study using advanced genomic techniques on samples from 43 breast cancer patients in Hong Kong revealed that NATs often had single-nucleotide variants (SNVs) in driver genes also found in tumor samples, but rarely had large-scale genomic changes.
- The researchers identified different evolutionary patterns among NAT and tumor pairs, indicating distinct genomic characteristics and the influence of the tumor microenvironment on cancer development.
Article Synopsis
- Testicular germ cell tumours (TGCT) are the most common cancers found in young men, including seminoma and non-seminoma types.
- This study uses whole genome sequencing to analyze adult TGCTs, providing a detailed genomic profile that includes mutations, structural variations, and DNA amplifications.
- The research uncovers correlations between genetic changes and the different growth patterns of TGCT subtypes, highlighting late genomic duplication in some cases and a common immune disruption mechanism in seminomas.
Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive description of its genomic landscape is lacking. Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer. Integrated analyses identify more than 250 putative CRC driver genes, many not previously implicated in CRC or other cancers, including several recurrent changes outside the coding genome.
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- Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of kidney cancer, and a study analyzed the genomes of 778 ccRCC patients to uncover its mutational characteristics.
- * The research identified key driver genes and emphasized the significance of epigenetic regulation, which may open up new treatment possibilities.
- * Findings included that patients with more structural copy number alterations had worse outcomes, while those with VHL mutations fared better; this work supports the idea that immune response plays a role in prognosis and could influence immunotherapy approaches.*
Kataegis, the focal hypermutation of single base substitutions (SBS) in tumour genomes, has received little attention with respect to prostate cancer (PCa) associated molecular and clinical features. Most notably, data is lacking with regards to this tumour evolutionary phenomenon and PCa racial disparities, with African men disproportionately impacted. Here through comparison between African (n = 109) and non-African (n = 79) whole genome sequenced treatment naïve primary tumours, using a single analytical workflow we assessed for shared and unique features of kataegis.
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