New formulation technology to boost sun protection.

Objective: As every skin type worldwide is concerned by photoprotection, with consumers preferring cosmetic elegant and efficient sunscreen products, we aim at developing the most performant and desirable sun care products.

Methods: We selected an interesting polymer, abbreviated AAHCP and designed scanning electron cryomicroscopy (cryoSEM), small angle and wide angle X-ray scattering and confocal laser scanning microscopy studies to understand its behaviour in solution and in simplex sun care formulations. This allowed us to develop innovative sunscreen formulation technology that was demonstrated by in vitro and in vivo photoprotection methods.

Endarterectomy, Stenting, or Medical Treatment for Symptomatic Carotid Near-Occlusion: Results from CAOS, a Multicenter Registry Study.

Background And Purpose: The treatment of symptomatic carotid near-occlusion is controversial. Our aim was to analyze the results of carotid endarterectomy and carotid artery stent placement in patients with symptomatic carotid near-occlusion and to identify factors related to technical failure, periprocedural complications, and restenosis.

Materials And Methods: We conducted a multicenter, prospective nonrandomized study.

Cerebral venous thrombosis in two patients with spontaneous intracranial hypotension.

Although few patients with spontaneous intracranial hypotension develop cerebral venous thrombosis, the association between these two entities seems too common to be simply a coincidental finding. We describe two cases of spontaneous intracranial hypotension associated with cerebral venous thrombosis. In one case, extensive cerebral venous thrombosis involved the superior sagittal sinus and multiple cortical cerebral veins.

[Safety of insulin analogues: what to evaluate, how to do it, and how to interpret the results].

The widespread use of insulin analogues is based not only on the pharmacokinetics of these preparations, which is much closer to the physiology of insulin secretion under normal conditions, but also on their safety and effectiveness. The publication of a possible association between the use of a long-acting insulin analogue (glargine) and breast cancer has caused uneasiness among the medical community regarding the safety of these analogues. The mechanism of increased tumor activity of insulin analogues is explained by the fact that they act through insulin receptors (IR) and insulin-like growth factor-1 (IGF-1R), stimulating cell growth and inhibiting apoptosis.