Publications by authors named "D E Swinson"
Background: Effective treatment for patients with metastatic cancer is limited, particularly for colorectal cancer patients with metastatic liver lesions (mCRC), where accessibility to numerous tumours is essential for favourable clinical outcomes. Oncolytic viruses (OVs) selectively replicate in cancer cells; however, direct targeting of inaccessible lesions is limited when using conventional intravenous or intratumoural administration routes.
Methods: We conducted a multi-centre, dose-escalation, phase I study of vaccinia virus, TG6002, via intrahepatic artery (IHA) delivery in combination with the oral pro-drug 5-fluorocytosine to fifteen mCRC patients.
Article Synopsis
- The global population is aging, and cancer rates are increasing, leading to more older adults living with cancer and requiring specialized care.
- Recent advancements in oncology, such as earlier diagnosis and diverse treatment options, highlight the importance of preparing health services to effectively care for older cancer patients who often have complex needs.
- This paper reviews the significant progress made in the UK in providing comprehensive geriatric assessments and new clinical services for older cancer patients, aiming to share these improvements with other healthcare systems.
Background: An improved understanding of which gastroesophageal adenocarcinoma (GOA) patients respond to both chemotherapy and immune checkpoint inhibitors (ICI) is needed. We investigated the predictive role and underlying biology of a 44-gene DNA damage immune response (DDIR) signature in patients with advanced GOA.
Materials And Methods: Transcriptional profiling was carried out on pretreatment tissue from 252 GOA patients treated with platinum-based chemotherapy (three dose levels) within the randomized phase III GO2 trial.
Objectives: This research aimed to replicate the Swinson, D., Snaith, J., Buckberry, J.
View Article and Find Full Text PDFObjectives: This study explored cancer pain management practices and clinical care pathways used by healthcare professionals (HCPs) to understand the barriers and facilitators for standardised pain management in oncology outpatient services (OS).
Design: Data were collected using semistructured interviews that were audio-recorded and transcribed. The data were analysed using thematic analysis.