Publications by authors named "D E Stringer"
Background: The choice of a single primary outcome in randomised trials can be difficult, especially in mental health where interventions may be complex and target several outcomes simultaneously. We carried out a systematic review to assess the quality of the analysis and reporting of multiple outcomes in mental health RCTs, comparing approaches with current CONSORT and other regulatory guidance.
Methods: The review included all late-stage mental health trials published between 1st January 2019 to 31st December 2020 in 9 leading medical and mental health journals.
Background: Despite the availability of evidence-based treatments for anorexia nervosa (AN), remission rates are moderate, and mortality is high. Olanzapine is used as adjunct therapy for AN in case of insufficient response to first-line treatments, even though the evidence is limited. Its effect on eating disorder (ED) psychopathology, its efficacy and tolerability, and its acceptability and adherence rate are unclear.
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- A study is being conducted on external trigeminal nerve stimulation (eTNS), a non-invasive device approved for treating ADHD, focusing on its long-term efficacy and mechanisms of action.
- The research involves a 4-week randomized controlled trial with 150 youths, comparing real eTNS to a sham treatment and assessing changes in ADHD symptoms, cognitive measures, and side effects.
- Results from this trial will help determine if eTNS can be a safe and effective alternative to medication for children and adolescents with ADHD.
Background: To provide precision cognitive remediation therapy (CR) for schizophrenia, we need to understand whether the mechanism for improved functioning is via cognition improvements. This mechanism has not been rigorously tested for potential moderator effects.
Study Design: We used data (n = 377) from a randomized controlled trial using CIRCuiTS, a therapist-supported CR, with participants from first-episode psychosis services.