The Impact of FDA-Approved Novel Agents for Steroid-Refractory Chronic Graft vs. Host Disease on Treatment Patterns and Outcomes-A Single-Center Longitudinal Cohort Analysis.

-chronic graft vs. host disease (cGVHD) is associated with substantial morbidity and mortality. We aimed to analyze advances in treatment strategy and outcomes during the last decade due to the incorporation of novel immunosuppressive therapy (IST) drugs in the armamentarium.

Heuristic energy-based cyclic peptide design.

Rational computational design is crucial to the pursuit of novel drugs and therapeutic agents. Meso-scale cyclic peptides, which consist of 7-40 amino acid residues, are of particular interest due to their conformational rigidity, binding specificity, degradation resistance, and potential cell permeability. Because there are few natural cyclic peptides, design involving non-canonical amino acids is a potentially useful goal.

Corrigendum: Bipartite networks represent causality better than simple networks: Evidence, algorithms, and applications.

[This corrects the article DOI: 10.3389/fgene.2024.

Bipartite networks represent causality better than simple networks: evidence, algorithms, and applications.

A network, whose nodes are genes and whose directed edges represent positive or negative influences of a regulatory gene and its targets, is often used as a representation of causality. To infer a network, researchers often develop a machine learning model and then evaluate the model based on its match with experimentally verified "gold standard" edges. The desired result of such a model is a network that may extend the gold standard edges.