Publications by authors named "D E Shafer"
Purpose: Relapsed and/or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome continue to have a poor prognosis with limited treatment options despite advancements in rational combination and targeted therapies. Belinostat (an HDAC inhibitor) and Pevonedistat (a NEDD8 inhibitor) have each been independently studied in hematologic malignancies and have tolerable safety profiles with limited single-agent activity. Preclinical studies in AML cell lines and primary AML cells show the combination to be highly synergistic, particularly in high-risk phenotypes such as p53 mutant and FLT-3-ITD positive cells.
View Article and Find Full Text PDFArticle Synopsis
- Limited research exists on mid-term outcomes of dental implants in patients with poor bone health, particularly postmenopausal women.
- This study involved 78 women, assessing the effects of different bone augmentation methods on implant stability using cone bean computed tomography (CBCT) scans at various stages.
- Results indicated that both healthy and compromised groups showed initial bone width increases, with healthy participants experiencing some height loss over time, whereas the compromised group maintained stability in height.
Novel Technique for Closed Reduction of an Irreducible Patella Dislocation in a Degenerative Knee.
J Am Acad Orthop Surg Glob Res Rev
October 2024
Article Synopsis
- - Patellar dislocations are common in young adults and often self-correct or can be fixed with closed reduction in the emergency room, but older adults face more complex issues due to degenerative changes in their knees.
- - A case report discusses a 60-year-old man whose traumatic patellar dislocation could not be resolved using standard closed reduction techniques because of an osteophyte on the femur blocking the patella.
- - The authors introduce a new closed reduction method for treating irreducible patellar dislocations, which has not been documented before in medical literature.
Osteochondromas are a common type of benign primary bone tumor rarely occurring in the scapula. When it is symptomatic, surgical removal is recommended. There are multiple approaches for surgical excision that can be used depending on the location and size of the tumor.
View Article and Find Full Text PDFArticle Synopsis
- Lunate and combination scaphoid-lunate fractures are uncommon injuries, with limited case reports available.
- A 16-year-old male experienced these fractures after hitting a goalpost, and he underwent successful surgery with headless compression screws.
- Follow-up at six months showed full recovery, despite initial complications with adherence to weight-bearing guidelines.