Publications by authors named "D E STABILE"
Article Synopsis
- Very low-calorie ketogenic diets (VLCKD) effectively aid weight loss in obese individuals and can decrease liver condition risks.
- Small extracellular vesicles (sEVs) from serum are studied in obese adults to see how they affect liver fibrosis and inflammation, with participants divided into low and high fibrosis risk groups.
- Results show that sEVs from low-risk patients improved liver health markers, while those from high-risk patients worsened inflammation and fibrosis signals, stressing the importance of assessing sEVs alongside traditional methods like FibroScan.
Objective: This study aims to explore the association between liver steatosis and fibrosis, as assessed by Fibroscan, and the onset of type 2 diabetes in overweight, medication-free men and women.
Methods: We analyzed data from 164 participants with overweight or obesity (41.4 % male), including 39 individuals (23.
Article Synopsis
- Early-stage gastric cancer often goes undetected due to a lack of specific symptoms, resulting in late diagnoses and advanced disease, highlighting the need for new biomarkers for early detection and treatment matching.
- The study investigated the prognostic significance of ENPP2/Autotaxin (ATX) and lysophosphatidic acid (LPA) in Gastro-Esophageal Adenocarcinoma (GEA), finding that higher levels of these substances could indicate worse patient outcomes.
- Results showed that while ENPP2 mutations are infrequent, they are linked to lower overall survival, and surgical removal of tumors significantly reduced serum ATX and LPA levels, suggesting potential for targeted therapies based on these biomarkers in future clinical trials.
Background: Colorectal cancer (CRC) is characterized by a pro-inflammatory microenvironment and features high-energy-supply molecules that assure tumor growth. A still less studied macromolecule is inorganic polyphosphate (iPolyP), a high-energy linear polymer that is ubiquitous in all forms of life. Made up of hundreds of repeated orthophosphate units, iPolyP is essential for a wide variety of functions in mammalian cells, including the regulation of proliferative signaling pathways.
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- The VLCKD diet helps in fat mobilization and reduces inflammation and liver issues in patients.
- The study focuses on how circulating extracellular vesicles (EVs) affect certain cellular processes and responses in patients undergoing an 8-week VLCKD regimen.
- Results indicate that while exosomes decrease cell viability, microvesicles do not, and reactive oxygen species (ROS) levels are consistent markers of diet adherence and may correlate more reliably with improvements in fibrotic response compared to ketone body levels.